The Nodes are the points of intersection between the path of the Sun and the Moon. The North Node is always opposite of the South Node. The North Node is where the Moon begins to move northward of the Sun’s path, the South Node is where the Moon begins to move southward of the Sun’s path. Accordingly, the North Node signifies what topics are rising and emerging in the world, and the South Node signifies what topics are falling away and out of favor in the world. Think of the North Node as an Ascendant for the entire planet Earth.
Here are the links to my interpretations of the Nodes in each sign of the zodiac: